Plasma Stability
The stability of a drug in plasma can strongly influence its effectiveness in vivo. Test articles in plasma are exposed to enzymatic processes (e.g., proteases, esterases) and can undergo intramolecular rearrangement or bind irreversibly (covalently) to proteins.
Test compounds are incubated at 37ºC with plasma (human and/or animal) and phosphate buffered saline (PBS). Aliquots are removed at 4 time points such as 0, 0.5, 1, and 2 hours, extracted, and analyzed for disappearance of parent compound, and the half-life (t1/2) of the article is estimated.
CLICK HERE TO READ MORE ABOUT PLASMA STABILITY
