Publication List
Hepatocyte Isolation & Culture
Gene Regulation
Drug-Drug Interaction
Induction
Inhibition
Drug Metabolism
Metabolic Stability/Profiling
Reaction Phenotyping
Cytotoxicity
Drug Transporters
CellzDirect Posters
Hepatocyte Isolation & Culture
Hewitt NJ, Lechon MJ, Houston JB, Hallifax D, Brown HS, Maurel P, Kenna JG, Gustavsson L, Lohmann C, Skonberg C, Guillouzo A, Tuschl G, Li AP, LeCluyse E, Groothuis GM, Hengstler JG. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab Rev. 39:159-234, 2007.
LeCluyse EL, Alexandre E, Hamilton GA, Viollon-Abadie C, Coon DJ, Jolley S, and Richert L Isolation and culture of primary human hepatocytes. Methods Mol. Biol. 290: 207-230, 2004.
Richert L, Binda D, Hamilton G, Alexandre E, Bigot-Lasserre D., Bars R, Coassolo P and LeCluyse E. Evaluation of the effect of culture configuration on morphology, survival time, antioxidant status and metabolic capacities of cultured rat hepatocytes. Toxicol. In Vitro 16: 89-99, 2002.
Susick R, Moss N, Kubota H, LeCluyse E, Hamilton G, Luntz T, Ludlow J, Fair J, Gerber D, Bergstrand K, White J, Bruce A, Drury O, Gupta S, and Reid LM. Hepatic progenitors and strategies for liver cell therapies. Ann. NY Acad. Sci. 944: 398-419, 2001.
LeCluyse EL. Pregnane X receptor: Molecular basis for species differences in CYP3A induction by xenobiotics. Chem. Biol. Interact. 134: 283-289, 2001.
LeCluyse EL. Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 enzyme expression and regulation. Eur. J. Pharm. Sci. 13: 343-368, 2001.
MacDonald JM, Xu ASL, Hiroshi K, LeCluyse E, Hamilton G, Liu H, Rong YW, Moss N, Lodestro C, Luntz T, Wolfe SP, and Reid LM. Ex Vivo Maintenance of Cells from the Liver Lineage. In: Methods of Tissue Engineering, Lanza, WL, Langer R, and Vacanti, J, eds, San Diego, CA Academic Press, 2001.
Hamilton GA, Jolley SL, Gilbert D, Coon DJ, Barros S, and LeCluyse EL. Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions. Cell Tiss. Res. 306: 85-99, 2001.
LeCluyse EL, Ahlgren-Beckendorf JA, Carroll K, Parkinson A, and Johnson J. Regulation of glutathione S-transferase enzymes in primary cultures of rat hepatocytes maintained under various matrix configurations. Toxicol. In Vitro 14:101-115, 2000.
LeCluyse EL, Bullock PL, Madan A, Carroll K and Parkinson A. Influence of extracellular matrix composition and medium formulation on the induction of cytochrome P450 2B enzymes in primary cultures of rat hepatocytes. Drug Metab. Dispos. 27: 909-915, 1999.
LeCluyse EL, Bullock P, Parkinson A and Hochman JH. Cultured rat hepatocytes. Pharm. Biotechnol. 8: 121-59, 1996.
LeCluyse EL, Bullock PL and Parkinson A. Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes. Adv. Drug. Del. Rev. 22: 133-186, 1996.
LeCluyse EL, Audus KL and Hochman JH. Formation of extensive canalicular networks by rat hepatocytes cultured in a collagen sandwich configuration. Am. J. Physiol. 266: C1764-C1774, 1994.
Gene Regulation
Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR. Human PXR forms a tryptophan zipper-mediated homodimer. Biochemistry. 45: 8579-89, 2006.
Graham RA, Goodwin B, Merrihew RV, Krol WL, Lecluyse EL. Cloning, tissue expression, and regulation of beagle dog CYP4A genes. Toxicol Sci. 92: 356-67, 2006.
Faucette SR, Sueyoshi T, Smith CM, Negishi M, Lecluyse EL, Wang H. Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor. J Pharmacol Exp Ther. 317: 1200-9, 2006.
Ferguson SS, Chen Y, LeCluyse EL, Negishi M, Goldstein JA..: Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. Mol Pharmacol. 68: 747-57, 2005.
Hempel N, Wang H, LeCluyse EL, McManus ME and Negishi M. The human sulfotransferase SULT1A1 gene is regulated in a synergistic manner by Sp1 and GA Binding Protein. Mol. Pharmacol. 66: 1690-701, 2004.
Wang H, and LeCluyse EL. Role of orphan nuclear receptors in the regulation of drug metabolising enzymes. Clin. Pharmacokinet. 42:1331-1357, 2003.
Ferguson SS, LeCluyse EL, Negishi M, and Goldstein JA. Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. Mol. Pharmacol. 62: 737-46, 2002.
Luo G, Cunningham M, Kim S, Burn T, Lin J, Sinz M, Hamilton G, Rizzo C, Jolley S, Gilbert D, Downey A, Mudra D, Graham R, Carroll K, Xie J, Madan A, Parkinson A, Christ D, Selling B, LeCluyse E, Gan LS. CYP3A4 induction by drugs: Correlation between a PXR reporter gene assay and CYP3A4 expression in human hepatocytes. Drug Met. Dispos. 30: 795-804, 2002.
LeCluyse EL, Madan A, Hamilton G, Carroll K, Dehaan R, and Parkinson A. Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. J. Biochem. Mol. Toxicol., 14: 177-188, 2000.
Zhu W, Song L, Matoney L, LeCluyse E, and Yan B: Dexamethasone differentially regulates the expression of carboxylesterase genes in humans and rats. Drug Metab. Dispos. 28: 186-191, 2000.
Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NC, LeCluyse EL, Lambert MH, Willson TM, Kliewer SA, Moore JT.: The pregnane X receptor, a promiscuous xenobiotic receptor that has diverged during evolution. Mol. Endocrinol. 14: 27-39, 2000.
Zhang H, LeCluyse E, Liu L, Hu M, Matoney L, Zhu W, and Yan B. Rat pregnane X receptor: Molecular cloning, tissue distribution and xenobiotic regulation. Arch. Biochem. Biophys. 368: 14-22, 1999.
Liu L, LeCluyse EL, Liu J and Klaassen CD. Sulfotransferase gene expression in primary cultures of rat hepatocytes. Biochem. Pharmacol. 52: 1621-1630, 1996.
Drug-Drug Interaction
Induction
Hewitt NJ, de Kanter R, LeCluyse E. Induction of drug metabolizing enzymes: a survey of in vitro methodologies and interpretations used in the pharmaceutical industry--do they comply with FDA recommendations? Chem Biol Interact. 168: 51-65, 2007.
Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, Negishi M, Wang H. Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. J Pharmacol Exp Ther. 320: 72-80, 2007.
Tang M, Mukundan M, Yang J, Charpentier N, LeCluyse EL, Black C, Yang D, Shi D, Yan B. Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol. J Pharmacol Exp Ther. 319: 1467-76, 2006.
Graham RA, Tyler LO, Krol WL, Silver IS, Webster LO, Clark P, Chen L, Banks T, LeCluyse EL. Temporal kinetics and concentration-response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes. J Biochem Mol Toxicol. 20: 69-78, 2006.
Smith CM, Graham RA, Krol WL, Silver IS, Negishi M, Wang H, Lecluyse EL. Differential UGT1A1 induction by chrysin in primary human hepatocytes and HepG2 Cells. J Pharmacol Exp Ther. 315: 1256-64, 2005.
Smith CM, Faucette SR, Wang H and LeCluyse EL. Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers. J. Biochem. Mol. Toxicol. 19: 96-108, 2005.
Sahi J, Stern RH, Milad MA, Rose KA, Gibson G, Zheng X, Stilgenbauer L, Sadagopan N, Jolley S, Gilbert D, and LeCluyse EL. Effects of Avasimibe on Cytochrome P450 2C9 Expression In Vitro and In Vivo. Drug Metab. Dispos. 32: 1370-1376, 2004.
Wang H, Faucette S, Moore R, Sueyoshi T, Negishi M, and LeCluyse E. Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. J. Biol. Chem. 279: 29295-29301, 2004.
Faucette S R, Wang H, Hamilton GA, Jolley SL, Gilbert D, Lindley C, Yan B, Negishi M, and LeCluyse EL. Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metab. Dispos. 32: 348-358, 2004.
Tippin TK, Hamilton G, Moore L, Beaudet EJ, Jolley S, Brodie TA, Andrews RC, Becherer JD, McDougald DL, Gaul MD, Hoivik DJ, Mellon-Kusibab K, Lehmann J, Kliewer S, Novick S, Laethem R, Zhao Z, LeCluyse EL. CYP3A induction by N-hydroxyformamide tumor necrosis factor-{alpha} converting enzyme/matrix metalloproteinase inhibitors: use of a pregnane X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans. Drug Metab. Dispos. 31: 870-877, 2003.
Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M, and LeCluyse EL. A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. J. Biol. Chem. 278: 14146-14152, 2003.
Wang H, Faucette SR, Gilbert D, Jolley SL, Sueyoshi T, Negishi M, and LeCluyse EL. Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes. Drug Metab. Dispos. 31: 620-630, 2003.
Madan A, Graham RA, Carroll KM, Mudra DR, Burton LA, Krueger LA, Downey AD, Czerwinski M, Forster J, Ribadeneira MD, Gan L-S, LeCluyse EL, Zech K, Robertson P, Koch P, Antonian L, Wagner G, Yu L, and Parkinson A. Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Met. Dispos. 31: 421-431, 2003.
Sahi J, Reyner EL, Bauman JN, Gueneva-Boucheva K, Burleigh JE, Thomas VH. Effect of bergamottin on diazepam pharmacokinetics and CYP3A4 activity in beagle dogs. Drug Metabolism and Disposition 30: 135-40. 2002.
Lindley C, Hamilton G, McCune J, Faucette S, Shord S, Hawke R, Wang H, Gilbert D, Jolley S, Yan B, and LeCluyse EL. The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes. Drug Met. Dispos. 30: 814-821, 2002.
Wen Y, Sahi, J, Urda, E, Kulkarni, S, Rose K, Zheng X, Sinclair J, Cai H, Strom S and Kostrubsky V. Effects of bergamottin on human and monkey drug metabolizing enzymes in primary cultured hepatocytes. Drug Metabolism and Disposition, 30: 977-984, 2002.
McCune JS, Hawke RL, LeCluyse EL, Gillenwater HH, Hamilton GA, Ritchie J, and Lindley C. In vivo and in vitro induction of human cytochrome P450 3A4 by dexamethasone. Clin. Pharmacol. Ther. 68: 356-366, 2000.
Sahi J, Hamilton G, Sinz M, Barros S, Huang S-M, Lesko LJ, and LeCluyse EL. The effect of troglitazone on CYP450 enzymes in primary cultures of human and rat hepatocytes. Xenobiotica, 30: 273-284, 2000.
Madan A, De Haan R, Mudra D, Carroll K, Marcucci K, LeCluyse EL, and Parkinson A. Effect of cryopreservation on cytochrome P450 enzyme induction in cultured rat hepatocytes. Drug Metab. Dispos. 27: 327-335, 1999.
Parkinson A, Madan A, Forster J, Carroll K, Marcucci K, DeHaan R, and LeCluyse E. Enzyme induction: Assessing the potential for drug interactions. In: Hori, W. (ed.) Drug-drug Interactions: Analyzing In Vitro - In Vivo Correlations, Southborough, MA: IBC Library Series, 1997.
Drug-Drug Interaction
Inhibition
Shi D, Yang J, Yang D, LeCluyse EL, Black C, You L, Akhlaghi F, Yan B. Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel. J Pharmacol Exp Ther. 319: 1477-84, 2006.
Sunman JA, Hawke RL, LeCluyse EL, and Kashuba ADM. Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. Drug Metab. Dispos. 32: 359-363, 2004.
Gang L, Lin J, Fiske WD, Dai R, Yang TJ, Kim S, Sinz M, LeCluyse E, Solon E, Brennan JM, Benedek IH, Jolley S, Gilbert D, Wang L, Lee FW, and Gan L-S. Concurrent induction and mechanism-based inactivation of CYP3A4 by an L-valinamide derivative. Drug Metab. Dispos. 31: 1170-1175, 2003.
Sahi J, Black C, Hamilton G, Zheng X, Jolley S, Rose K, Gilbert D, LeCluyse E and Sinz M. Comparative effects of thiazolininediones on in vitro P450 enzyme induction and inhibition. Drug Met. Dispos. 31: 439-446, 2003.
Drug Metabolism
Metabolic Stability/Profiling
Cameron MD, Wright J, Black CB, and Ye, N. In vitro Prediction and in vivo Verification of Enantioselective Human Tofisopam Metabolite Profiles. Fast Forward Publication Drug Met. Dispos. July 23, 2007.
Drobna Z, Waters SB, Walton FS, LeCluyse EL, Thomas DJ, and Styblo M. Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes. Toxicol. Appl. Pharmacol. 201:166-77, 2004.
Hill JR, In Vitro Drug Metabolism Using Liver Microsomes, Current Protocols in Pharmacology, Ed. John Wiley and Sons, Unit 7.8, 7.8.1-7.8.12, 2004.
Walton FS, Waters SB, Jolley SL, LeCluyse EL, Thomas DJ, and Styblo M. Selenium compounds modulate the activity of recombinant rat as III -methyltransferase and the methylation of arsenite by rat and human hepatocytes. Res. Chem. Tox. 16: 261-265, 2003.
Faucette SR, Hawke RL, Shord SS, LeCluyse EL, and Lindley C. Evaluation of the contribution of cytochrome P450 3A4 to human liver microsomal bupropion hydroxylation. Drug Metab. Dispos. 29: 1123-1129, 2001.
Faucette SR, Hawke RL, LeCluyse EL, Shord SS, Yan B, Laethem RM, and Lindley CM. Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity. Drug Metab. Dispos. 28: 1222-1230, 2000.
Styblo M, Del Razo LM, LeCluyse EL, Hamilton GA, Wang C, Cullen WR and Thomas D. Methylation of arsenic in primary cultures of human and rat hepatocytes. Chem. Res. Toxicol. 12: 560-565, 1999.
Black CB and Cowan JA. Magnesium-Dependent Enzymes in General Metabolism. Cowan, JA, Ed. The Biological Chemistry of Magnesium Ed., VCH Publishers, Inc., New York, NY, 159-183, 1995.
Reaction Phenotyping
Williams JA, Bauman J, Cai H, Conlon K, Hansel S, Hurst S, Sadagopan N, Tugnait M, Zhang L and Sahi J. In vitro ADME phenotyping in drug discovery: current challenges and future solutions. Curr Opin Drug Discov Devel 8: 78-88, 2005.
Cytotoxicity
Lu T, Liu J, LeCluyse EL, Zhou YS, Cheng ML, Waalkes MP. Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China. Toxicol. Sci. 59: 185-192, 2001.
Styblo M, Del Razo LM, Vega L, Germolec DR, LeCluyse EL, Hamilton GA, Reed W, Wang C, Cullen WR, and Thomas DJ. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Arch. Toxicol. 74: 289-299, 2000.
Liu D-Z, LeCluyse EL, and Thakker DR: Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers. J. Pharm. Sci. 88: 1161-1168, 1999.
Drug Transporters
Hoffmaster KA, Turncliff RZ, LeCluyse EL, Kim RB, Meier PJ, and Brouwer KL. P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide. Pharm Res. 21: 1294-302, 2004.
Mills JB, Rose KA, Sadagopan N, Sahi J, de Morais SM. Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line. J Pharmacol Exp Ther, 309: 303-309, 2004.
Kostrubsky VE, Strom SC, Hanson J, Urda E, Rose K, Burliegh J, Zocharski P, Cai H, Sinclair JF and Sahi J. Evaluation of hepatotoxic potential of drugs by inhibition of bile acid transport in cultured primary human hepatocytes and intact rats. Toxicological Sciences 76: 220-228, 2003.
Sahi J, Milad MA, Zheng X, Rose KA, Wang H, Stilgenbauer L, Gilbert D, Jolley S, Stern RH, LeCluyse EL.: Avasimibe induces CYP3A4 and MDR1 gene expression through activation of the pregnane X receptor. J. Pharmacol. Exp. Ther. 306: 1027-1034, 2003.
Alrefai WA, Tyagi S, Nazir TM, Barakat J, Anwar SS, Hadjiagapiou C, Bavishi D, Sahi J, Malik P, Goldstein J, Layden TJ, Ramaswmy K and Dudeja PK. Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization. Biochim. Biophys. Acta. 1511: 17-27, 2001.
Chandra P, LeCluyse EL and Brouwer KL. Optimization of culture conditions for determining hepatobiliary disposition of taurocholate in sandwich-cultured rat hepatocytes. In Vitro Cell. Dev. Biol. 37: 380-385, 2001.
LeCluyse EL, Fix JA, Audus KL and Hochman JH. Regeneration and maintenance of bile canalicular networks in collagen-sandwiched hepatocytes. Toxicol. In Vitro 14: 117-132, 2000.
Venkatasubramanian J, Sahi J, and Rao MC. Ion transport during growth and differentiation. Annals of New York Academy of Sciences, 91: 5357-72, 2000.
Liu X, LeCluyse EL, Brouwer KR, Gan L-SL, LeMasters JJ, Stieger B., Meier PJ, and Brouwer KLR. Biliary excretion in primary rat hepatocytes cultured in a collagen sandwich configuration. Am. J. Physiol. 277: G12-21, 1999.
Liu X, Chism JP, LeCluyse EL, Brouwer KR, and Brouwer KL. Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats. Drug Metab. Dispos. 27: 637-644, 1999.
Liu X, LeCluyse EL, Brouwer KR, Lightfoot RM, Lee JI, Brouwer KL. Use of Ca2+ modulation to evaluate biliary excretion in sandwich-cultured rat hepatocytes. J. Pharmacol. Exp. Ther. 289: 1592-1599, 1999.
Liu X, Brouwer KL, Gan LS, Brouwer KR, Stieger B, Meier PJ, Audus KL, LeCluyse EL. Partial maintenance of taurocholate uptake by adult rat hepatocytes cultured in a collagen sandwich configuration. Pharm. Res. 15: 1533-1539, 1998.
Sahi, J, SG Nataraja, TJ Layden, JL Goldstein, MP Moyer and MC Rao. Chloride transport in an immortalized human epithelial cell line (NCM460) derived from the human transverse colon. Am. J. Physiol. 275: C1048-C1057, 1998.
Desai GN, Sahi J, Reddy PM, Venkatasubramanian J, Vidyasagar D, Rao MC. Chloride transport in primary cultures of rabbit colonocytes at different stages of development. Gastroenterology, 111: 1541-1550, 1996.
Sahi J, Wiggins MP, Gibori GB, Layden TJ and Rao MC. Calcium regulated chloride permeabilities in primary cultures of rabbit colonocytes. Journal of Cellular Physiology, 168:276-283, 1996.
Sahi J, Goldstein JL, Layden TJ and Rao MC. Cyclic AMP and phorbol ester regulated chloride permeability’s in primary cultures of human and rabbit colonocytes. American J. Physiology: Gastrointestinal and Liver Physiology 266: G846 G855, 1994.
Goldstein JL, Sahi J, Bhuva M, Layden TJ and Rao MC. E.coli Heat stable enterotoxin (STa) mediated colonic Cl secretion is absent in cystic fibrosis (CF). Gastroenterology 107: 950 956, 1994.
CellzDirect Posters
Regulation of CYP2C9 Expression in Primary Cultures of Human Hepatocytes. J Sahi, S Shord, S Ferguson, and EL LeCluyse, ISSX 8th International Meeting, Sendai, Japan, 2007
Evaluation of the in Vitro Induction Potential of Xenobiotics Known to be Transactivators of Human Pregnane X Receptor (hPXR). J. Sahi, S Ferguson, EL LeCluyse, and M Sinz, ISSX 8th International Meeting, Sendai, Japan, 2007
Effect of BDE-47 on hepatic drug metabolizing enzymes in isogenic Rainbow Trout (Oncorhynchus mykiss). J Sahi, K Johanning, J Wright, J Stover, L Easterwood, J Hill and I Schultz. Poster Presentation: Society of Toxicology 46th Annual Meeting, Charlotte, North Carolina, 2007. Oral Presentation: SETAC Europe 17th Annual Meeting, Porto, Portugal, 2007.
Comparison of in vitro Phase I and II Metabolic Activity Assays Between Rainbow Trout (Oncorhynchus mykiss) and Human Hepatic Microsomes and S9 Fractions. K Johanning, J Stover, J Wright, L Easterwood, C Black, I Schulz, J Hill and J Sahi. Society of Toxicology 46th Annual Meeting, Charlotte, North Carolina, 2007.
Investigation of the Induction Properties of HMG-CoA Reductase Inhibitors Cerivastatin, Simvastatin, Atorvastatin, Pravastatin, and Fluvastatin in Cultures of Primary Human Hepatocytes. S Ferguson, J Wright, M Pawlowski, J Hatfield, C Baucom, M Smith, J Stover, B Yan, and EL LeCluyse. North American ISSX 14th Annual Meeting, Rio Grande, Puerto Rico, 2006.
Comparison of in vitro Metabolic Activity Between Rainbow Trout (Oncorhynchus mykiss)
and Human Liver Subcellular Fractions. L Easterwood, J Stover, J Wright, C Black, J Sahi and J Hill. North American ISSX 14th Annual Meeting, Rio Grande, Puerto Rico, 2006.
Evaluation of Gene Expression Differences between Fa2N Cells and Cultured Human Hepatocytes using Affymetrix HGU133 2.0 GeneChips. A Williams, A Ellis, M Obusek, S Otmani, MD Ribadeneira, S Ferguson, S Grimm and EL LeCluyse. North American ISSX 14th Annual Meeting, Rio Grande, Puerto Rico, 2006.
A Mechanism Based Strategy For Assessing Induction Of Hepatic Drug-Metabolizing Enzymes In Vitro; H Wang, T Luntz, S Faucette, G Hamilton, S Ferguson, C Black, K Khan, M Cameron, E Chacon J Goldstein, M Negishi and EL LeCluyse. North American ISSX 12th Annual Meeting, Vancouver, British Columbia, 2004.
Investigation of Aldehyde Oxidase Activity in Human, Monkey, Dog, Rat and Mouse Cytosols and Cryopreserved Hepatocytes. KK Khan, MD Cameron, JK Wright, and CB Black. North American ISSX 12th Annual Meeting, Vancouver, British Columbia, 2004.
In Vitro Prediction of Hepatic Clearance: Evaluation of Individual Variance for 10 Substratres; M Cameron, K Khan, J Wright, B Rodriguez, B Fontenot, and C Black. North American ISSX 12th Annual Meeting, Vancouver, British Columbia, 2004.
The Content of Cytochrome P450 3A5 in Human Liver Microsomes Affects the Degree of
Inactivation by Mifepristone (RU486), KK Khan, MJ Shaw, MD Cameron, CW Fisher and CB Black. North American ISSX 11th Annual Meeting, Orlando Florida, 2003.
Characterization of Human Liver Microsomal Tolbutamide Hydroxylation from a CYP2C9 *2/*2 Individual, CW. Fisher, KK Khan, MD Cameron and CB Black. North American ISSX 11th Annual Meeting, Orlando Florida, 2003.
Comparison of in situ vs. Microsomal Evaluation of CYP Induction in Rat and Human Hepatocytes: Determination of Apparent CYP Kinetics. MD Ribadeneira, D Zhou, CB Black, K Wright, G Hamilton, EL LeCluyse and S Grimm.
Effect of Rho Family Small GTPases on the Cell Adehesion-dependent expression of CYP3A4 in Primary Human Hepatocytes, DJ Coon, J Olsen, GA Hamilton, K Burridge, EL LeCluyse.
